How to Get to Clinically Relevant Research The default method to evaluate clinical research is by statistical significance Unfortunately is statistical significance not related to the meaningfulness of the findings in the research and thereby to...
How to Get to Clinically Relevant Research
The default method to evaluate clinical research is by statistical significance
Unfortunately is statistical significance not related to the meaningfulness of the findings in the research and thereby to its meaningfulness for patients and healthcare
If researchers stated ahead of starting the trial what they would consider clinically relevant, the reader could relate to that and agree or disagree with the researcher
It would come from focusing on using the provided information to help patients and improve healthcare - and not just publishing a paper
We want to make it mandatory to state the researchers' clinical relevance levels ahead of the trial, mentioning what they will consider clinically relevant when they pre-register their research on the clinicaltrials.gov website or similar websites. They then need to compare their findings in both the paper and abstract when publishing data from the study. #clinicalrelevance
A specific page on our website about requesting clinical relevance statement and evaluation https://www.precision-evidence.com/p/clinical-relevance/
The history behind the chosen level for statistical significance with Ronald Fisher's book from 1925 "Statistical Methods for Research Workers." Precision Evidence Blog: https://www.precision-evidence.com/blog/the-p-value-and-sir-ronald-fischer/
96% of published studies mention a p-value at 0.05 or lower: "What Have We (Not) Learned from Millions of Scientific Papers with P Values?" https://www.tandfonline.com/doi/full/10.1080/00031305.2018.1447512
Overview of clinical trials registers like clinicaltrials.gov: https://sites.google.com/a/york.ac.uk/yhectrialsregisters/home/clinicaltrials
Precision Evidence #8: "Critical Appraisal of the Moderna COVID19 Vaccine Trial"
Precision Evidence #6: "Covid-19 Vaccines Trials: Understanding the First Published Results" https://www.precision-evidence.com/6
Precision Evidence #5: "Covid-19 Vaccines Trials and Press Releases – Looking Beyond the Efficacy" https://www.precision-evidence.com/5
TED talk with Sir Ken Robinson where he talks about two kinds of people https://www.ted.com/talks/sir_ken_robinson_bring_on_the_learning_revolution
GET THE ABSTRACT SCREENING TOOL
It can be a challenge to screen papers for clinical relevance. As we go beyond the abstract in this podcast, we have created a screening tool you can use when reading an abstract from a clinical research paper.
Using that tool enables you to quickly screen an abstract from a medical journal for clinical relevance selecting only those you want to read. At the same time, you will know why you skipped the rest. Get it at our website https://www.precision-evidence.com
Contact us at email: firstname.lastname@example.org,
You can learn more at our website, where you can also leave us a voice message
Get the Precision Evidence Newsletter https://bit.ly/3tLBx3Z
Dr. Kim Kristiansen, M.D: @KKristiansenMD
JG Staal: @HealthyEvidence
Music thanks to mixkit.co