Feb. 2, 2021

Critical Appraisal of the Moderna COVID19 Vaccine Trial #8

Critical Appraisal of the Moderna COVID19 Vaccine Trial #8

Critical Appraisal of the Moderna COVID19 Vaccine Trial There is a big interest in clinical research now due to the Covid19 pandemic Especially the trails behind the Covid vaccines gain interest and is all over the news In this episode, we take a...


Critical Appraisal of the Moderna COVID19 Vaccine Trial

  • There is a big interest in clinical research now due to the Covid19 pandemic
  • Especially the trails behind the Covid vaccines gain interest and is all over the news
  • In this episode, we take a look at the published paper on the Moderna vaccine trial using our last episode of this podcast (#7) about the precision of the evidence
  • We know from the news that the outcome in the Moderna vaccine trial is good with a reduction in risk at 94.1% by getting the vaccine
  • But is the study as a whole clinically relevant and trustworthy?
  • And how many people need to be given the vaccination to prevent one COVID19 infection? - Probably not what you would guess
  • We will cover this and much more in this episode

GET THE ABSTRACT SCREENING TOOL

It can be a challenge to screen papers for clinical relevance. As we go beyond the abstract in this podcast, we have created a screening tool you can use when reading an abstract from a clinical research paper.

Using that tool enables you to quickly screen an abstract from a medical journal for clinical relevance selecting only those you want to read. At the same time, you will know why you skipped the rest. Get it at our website https://www.precision-evidence.com 

 LINKS:

Moderna vaccine trial interim analysis paper (full access) https://www.nejm.org/doi/full/10.1056/NEJMoa2035389 

Moderna vaccine trial interim analysis on clinicaltrials.gov  https://clinicaltrials.gov/ct2/show/NCT04470427 

Evaluating clinical relevance in 2 x 2 matrix https://www.precision-evidence.com/matrix

Precision Evidence #7 https://www.precision-evidence.com/7 

Precision Evidence #6 https://www.precision-evidence.com/6 

Precision Evidence #5 https://www.precision-evidence.com/5 

 

NOTES:

 

  • Moderna vaccine trial has a somewhat confusing abstract
  • Efficacy is high at 94.1%  - and what that means in real life
  • It is statistically significant, but is it also clinically significant and relevant?
  • Stating what to be regarded clinically significant BEFORE stating the trial is important!
  • A closer look at study population and dropouts
  • A closer look at randomization and study period
  • The study on clinicaltrials.gov compared with paper, what can we learn?
  • How many persons need to be given the vaccination to prevent one COVID19 infection? - Probably not what you would guess
  • Safety and other vaccines
  • What we still need to know
  • Phase 3 vs Phase 4 trials
  • Conclusion
  • Future episodes of the Precision Evidence Podcast

 

 

 Contact us at email: podcast@precision-evidence.com,

Twitter @PrecisionEBM,

You can learn more at our website, where you can also leave us a voice message 

Website: www.precision-evidence.com

Hosts:

Dr. Kim Kristiansen, M.D: @KKristiansenMD

JG Staal: @HealthyEvidence

PRECISION EVIDENCE ON TOP LIST

Precision Evidence has been selected by Feedspot to the list of  

Top 35 Clinical Trials Podcasts You Must Follow in 2021

https://blog.feedspot.com/clinical_trials_podcasts/ 

 

Music thanks to mixkit.co